FIRE

Everybody deserves to be treated differently

FIRE™, a revolution in simplicity, sample throughput and sensitivity

We use the patented Adduct FIRE method to analyze blood samples. The method is highly sensitive and can be used to quantify reactive substances that binds covalently to bio-markers and are otherwise very hard to access. The analyses can be run both on blood and on purified cells.

The Adduct FIRE procedure offers:

Around 20 times higher sample through put than the N-alkyl Edman procedure
State of the art performance on LC-MS/MS instruments
Adduct measurements in whole blood – saves time and opens up for analysis on whole blood samples in biobanks
Small amount of blood needed, 250 µL/sample on routine basis
Well documented performance on thousands of samples including cord blood
Excellence in analyzing a broad variety of adducts including ionic, thermolabile, and high molecular weight adducts
Swedish patented technology. Developed at Stockholm University by true pioneers in the field of adduct measurements
Advanced knowledge in customized synthesis of reference compounds and isotope substituted internal standards

The FIRE™ procedure to measure individual levels of active CPA

Cyclophosphamide is transformed to PAM through an enzymatic reaction in the liver. PAM cross links DNA to achieve the cytotoxic effect and, in a parallel reaction, forms a stable Hb adduct that can be quantified by the FIRE™ procedure to obtain a measurement of the individual internal dose of PAM in RBS accumulated over time.

FIRE

Everybody deserves to be treated differently

FIRE™, a revolution in simplicity, sample throughput and sensitivity

The Adduct FIRE procedure offers:

The FIRE™ procedure to measure individual levels of active CPA

TailorDose

TailorDose-CPA

Adduct FIRE-method

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